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Product name : MK 2461
Item : cc600
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 917879-39-1
Molecular Weight : 495.55
Formula : C₂₄H₂₅N₅O₅S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
MK-2461 is a potent inhibitor of c-Met, Ron, Flt1, Flt 3, PDGFRβ, and Mer with IC50 of 2.5 nM, 7 nM, 10 nM, 22 nM, 22 nM and 24 nM, respectively. In tumor cells, MK2461 effectively suppressed constitutive or ligand-induced phosphorylation of the juxtamembrane domain and COOH-terminal docking site of c-Met, and its downstream signaling to the phosphoinositide 3-kinase–AKT and Ras–extracellular signal-regulated kinase pathways, without inhibiting autophosphorylation of the c-Met activation loop.  [1][2]
 
Reference:
[1] Cancer Res. 2010, 70, 1524-1533.
[2] Anal. Biochem. 1999, 269, 94-104.
 
 
Chemical Information
Molecular Weight (WM):
495.55
Formula:
C24H25N5O5S
CAS No:
917879-39-1, 1196681-15-8, 1170702-87-0 (sodium salt)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 99 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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