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Product name : Ki 8751
Item : cc604
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 228559-41-9
Molecular Weight : 469.41
Formula : C₂₄H₁₈F₃N₃O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Ki8751 is a potent and selective inhibitor to VEGFR-2 with IC50 of 0.9 nM. Ki-8751 displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Ki 8751 inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo.   [1][2]
 
Reference:
[1] J Med. Chem. 2005, 1359-1366.
[2] Cancer Sci. 2010, 101, 1403-1408.
 
 
Chemical Information
Molecular Weight (WM):
469.41
Formula:
C24H18F3N3O4
CAS No:
228559-41-9
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 94 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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