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Product name : GSK 1059615
Item : cc609
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 958852-01-2
Molecular Weight : 333.36
Formula : C₁₈H₁₁N₃O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
GSK1059615 is a novel and dual inhibitor of phosphoinositide 3-kinases (PI3Kα, β, δ, and γ) and mammalian target of rapamycin (mTOR) with IC50 of 0.4-12 nM. GSK 1059615 inhibits PI3K signaling, induces G1 arrest and apoptosis, especially in breast tumor cells. In T47D and BT474 cancer cells, GSK-1059615 inhibits the phosphorylation of Akt at S473, with IC50 of 40 nM.  [1][2]
 
Reference:
[1] Expert Opin. Investig. Drugs 2009, 18, 1265-1277.
[2] Curr. Top Microbiol. Immunol. 2010, 347, 209-239.
 
 
Chemical Information
Molecular Weight (WM):
333.36
Formula:
C18H11N3O2S
CAS No:
958852-01-2, 1356195-42-0 (H2O. Na)
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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