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Product name : PIK 294
Item : cc610
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 900185-02-6
Molecular Weight : 489.53
Formula : C₂₈H₂₃N₇O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PIK-294 is a highly potent and selective p110δ inhibitor with IC50 of 10 nM. PIK294 is a PI3 Kinase inhibitor that is 20- to 60-fold more potent than the parent compound, PIK-293. PIK 294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 μM). The m-phenol moiety of PIK 294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity. [1][2]
 
Reference:
[1] Cell 2006, 125, 733-747.
[2] Mol. Cell Biol. 2012, 32, 2268-2278.
 
 
Chemical Information
Molecular Weight (WM):
489.53
Formula:
C28H23N7O2
CAS No:
900185-02-6
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 98 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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