Product name : Triciribine
Item : cc615
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 35943-35-2
Molecular Weight : 320.3
Formula : C₁₃H₁₆N₆O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt phosphorylation and HIV-1 with IC50 with 130 nM and 20 nM, respectively. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9. [1][2]
Reference:
[1] Clin. Cancer Res. 2007, 13, 5883-5888.
[2] Cancer Res. 2004, 64, 4394-4399.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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