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Product name : GDC 0068
Item : cc616
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1001264-89-6
Molecular Weight : 458.0
Formula : C₂₄H₃₂ClN₅O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively. GDC-0068 only inhibits 3 kinases by >70% at 1 μM concentration (PRKG1α, PRKG1β, and p70S6K, with IC50 of 98 nM, 69 nM, and 860 nM, respectively). GDC0068 displays >100-fold selectivity for Akt over PKA with IC50 of 3.1 μM. GDC 0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by Akt signaling   [1][2]
 
Reference:
[1] J Med. Chem. 2012, 55, 8110-8127.
[2] Cancer Res. 2012, 72, 8 966.
 
 
Chemical Information
Molecular Weight (WM):
458.00
Formula:
C24H32ClN5O2
CAS No:
1001264-89-6
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 92 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 92 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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