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Product name : MK 5108 (VX 689)
Item : cc619
Price : 10mg, $275; 50mg, $695; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
MK-5108 (VX-689) is a highly selective Aurora-A kinase inhibitor with an IC50 of 0.064 nM. MK5108 (VX689) inhibited growth of human tumor cell lines in culture and in different xenograft models. Furthermore, the combination of MK 5108 and docetaxel showed enhanced antitumor activities compared with control and docetaxel alone-treated animals without exacerbating the adverse effects of docetaxel.  [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 157-166.
[2] Clin. Cancer Res. 2012, 18, 3352-3365.
 
 
Chemical Information
Molecular Weight (WM):
461.94
Formula:
C22H21ClFN3O3S
CAS No:
1010085-13-8
Purity:
≥ 98%
Synonyms:
VX 689
 
DMSO ≥ 35 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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