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Product name : BI 2536
Item : cc627
Price : 10mg, $175; 50mg, $495; 100mg, $645; 200mg, $995
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
BI-2536 is a potent polo-like kinase 1 (Plk1) inhibitor with IC50 of 0.83 nM. BI2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI 2536 displays more than 1000-fold selectivity relative to a panel of 63 other protein kinases with IC50 of >10 μM. Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM.  [1][2]
 
Reference:
[1] Curr. Biol. 2007, 17, 316-322.
[2] Cancer Res. 2009, 69, 1916-1923.
 
 
Chemical Information
Molecular Weight (WM):
521.65
Formula:
C28H39N7O3
CAS No:
755038-02-9, 876126-71-5 (H2O)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 104 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 104 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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