Apoptosis
Aurora Kinase
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Product name : BI 2536
Item : cc627
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 755038-02-9
Molecular Weight : 521.65
Formula : C₂₈H₃₉N₇O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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BI-2536 is a potent polo-like kinase 1 (Plk1) inhibitor with IC50 of 0.83 nM. BI2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI 2536 displays more than 1000-fold selectivity relative to a panel of 63 other protein kinases with IC50 of >10 μM. Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [1][2]
Reference:
[1] Curr. Biol. 2007, 17, 316-322.
[2] Cancer Res. 2009, 69, 1916-1923.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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