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Product name : GSK 461364
Item : cc630
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 929095-18-1
Molecular Weight : 543.6
Formula : C₂₇H₂₈F₃N₅O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
GSK461364 is a thiophene amide that inhibits purified Plk1 enzyme with Ki of 2 nM.  GSK-461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.  [1][2]
 
Reference:
[1] Clin. Cancer Res. 2011, 17, 3420-3430.
[2] Cancer Res. 2009, 69, 6969-6977.
 
 
Chemical Information
Molecular Weight (WM):
543.60
Formula:
C27H28F3N5O2S
CAS No:
929095-18-1, 1000873-97-1
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 10 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 63 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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