Apoptosis
Aurora Kinase
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Product name : GSK 461364
Item : cc630
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 929095-18-1
Molecular Weight : 543.6
Formula : C₂₇H₂₈F₃N₅O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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GSK461364 is a thiophene amide that inhibits purified Plk1 enzyme with Ki of 2 nM. GSK-461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. [1][2]
Reference:
[1] Clin. Cancer Res. 2011, 17, 3420-3430.
[2] Cancer Res. 2009, 69, 6969-6977.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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