Apoptosis
Aurora Kinase
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Product name : TAK 960
Item : cc631
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1137868-52-0
Molecular Weight : 561.6
Formula : C₂₇H₃₄F₃N₇O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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TAK-960 is a novel, potent and selective PLK1 inhibitor with IC50 of 8 nM. TAK960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis. [1]
Reference:
[1] Mol. Cancer Ther. 2012, 11, 700-709.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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