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Product name : GSK 429286A
Item : cc634
Price : 10mg, $195; 50mg, $595; 100mg, $895; 200mg, $1355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. GSK-429286A is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2).  [1][2]
 
Reference:
[1] J Med. Chem. 2007, 50, 6-9.
[2] Biochem. J 2009, 424, 47-60.
 
 
Chemical Information
Molecular Weight (WM):
432.37
Formula:
C21H16F4N4O2
CAS No:
864082-47-3
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 87 mg/mL
Solubility (25℃)
Water ≥ 87 mg/mL
 
Ethanol ≥ 17 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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