Favorite  |  Set Home
Products > PI3K/Akt/mTOR > Akt > AZD 5363
Product name : AZD 5363
Item : cc638
Price : 10mg, $275; 50mg, $795; 100mg, $1395; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
AZD 5363 is a novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD-5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers.  [1]
 
 Reference:
[1] Mol. Cancer Ther. 2012, 11, 873-883.
 
 
Chemical Information
Molecular Weight (WM):
428.92
Formula:
C21H25ClN6O2
CAS No:
1143532-39-1
Purity:
≥ 98%
Synonyms:
AZD5363
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
BX 795
BX 795
Price: 10mg, $125; 50mg, $495; 100mg, $995; 200mg, $1695
AT 7867
AT 7867
Price: 10mg, $245; 50mg, $825; 100mg, $1295; 200mg, $2295
GSK 690693
GSK 690693
Price: 10mg, $140; 50mg,$595; 100mg, $895; 200mg,$1895
PHT 427
PHT 427
Price: 10mg, $55; 50mg, $195; 100mg, $345; 200mg, $645
Akt Inhibitor IV
Akt Inhibitor IV
Price: 10mg, $275; 50mg, $895; 100mg, $1345; 200mg, $2195
Isobavachalcone
Isobavachalcone
Price: 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1455
A 674563
A 674563
Price: 10mg, $455; 50mg, $1495; 100mg, $1995; 200mg,$2795
CCT 128930
CCT 128930
Price: 10mg, $245; 50mg, $825; 100mg, $1395; 200mg, $2295