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Products > Receptor Tyrosine Kinase > Flt > NVP-AST 487 (AST 487)
Product name : NVP-AST 487 (AST 487)
Item : cc640
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 630124-46-8
Molecular Weight : 529.56
Formula : C₂₆H₃₀F₃N₇O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
AST 487, novel first-generation ‘type II’ FLT3 inhibitor, potently and selectively targets mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. AST-487, which selectively targets mutant FLT3 protein kinase activity, is also shown to override PKC412 resistance in vitro, and has significant antileukemic activity in an in vivo model of FLT3-ITD+ leukemia. Finally, the combination of NVP-AST487 with standard chemotherapeutic agents leads to enhanced inhibition of proliferation of mutant FLT3-expressing cells. [1][2]
 
 
Reference:
[1] Cancer Res. 2007, 67, 6956-6964.
[2] Blood 2008, 112, 5161-5170.
 
 
 
Chemical Information
Molecular Weight (WM):
529.56
Formula:
C26H30F3N7O2
CAS No:
630124-46-8
Purity:
≥ 98%
Synonyms:
AST487
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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