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Product name : CCG 50014
Item : cc641
Price : 10mg, $125; 50mg, $495; 100mg, $795; 200mg, $1095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
CCG-50014, the most potent small molecule RGS inhibitor to date has an IC(50) for RGS4 of 30 nM and is >20-fold selective for RGS4 over other RGS proteins. CCG50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG 50014 is not a general cysteine alkylator as it does not inhibit activity of the cysteine protease papain at concentrations >3000-fold higher than those required to inhibit RGS4 function. It is also >1000-fold more potent as an RGS4 inhibitor than are the cysteine alkylators N-ethylmaleimide and iodoacetamide. [1][2]
 
 
Reference:
[1] Biochemistry 2011, 50, 3181-3192.
[2] ACS Med. Chem. Lett. 2012, 3, 146-150.
 
 
 
Chemical Information
Molecular Weight (WM):
316.35
Formula:
C16H13FN2O2S
CAS No:
883050-24-6
Purity:
≥ 98%
Synonyms:
CCG 50014
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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