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Product name : UNC 0638
Item : cc 643
Price : 10mg, $125; 50mg, $595; 100mg, $895; 200mg, $1295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
UNC-0638 is an inhibitor of G9a and GLP with excellent potency (IC50 < 20nM) and selectivity over a wide range of epigenetic and non-epigenetic targets. The histone methyltransferase (HMTase) G9a can mono-or dimethylate lysine 9 on histone 3, contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC 0638 markedly reduced the clonogenicity of MCF7 cells, reduced the abundance of H3K9me2 marks at promoters of known G9a-regulated endogenous genes and disproportionately affected several genomic loci encoding microRNAs.  [1][2]
 
Reference:
[1] Anal. Biochem. 2010, 86-93.
[2] J Med. Chem. 2008, 51, 7053-7056.
 
 
Chemical Information
Molecular Weight (WM):
509.73
Formula:
C30H47N5O2
CAS No:
1255580-76-7
Purity:
≥ 98%
Synonyms:
UNC 0638
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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