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Product name : TDZD 8
Item : cc 646
Price : 10mg, $125; 50mg, $475; 100mg, $795; 200mg, $1095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
TDZD-8 is a noncompetitive GSK-3β inhibitor. GSK-3β is abundant in the central nervous system, particularly in the hippocampus, and plays a pivotal role in the pathophysiology of a number of diseases, including neurodegeneration. TDZD8 protects the brain against I/R injury by inhibiting GSK-3β activity. TDZD 8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells.[1][2]
 
Reference:
[1] FASEB J. 2004, 18, 1162-1164.
[2] Endocrinology. 2005, 146, 3141-3149.
 
 
Chemical Information
Molecular Weight (WM):
222.26
Formula:
C10H10N2O2S
CAS No:
327036-89-5
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 44 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 44 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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