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Product name : Apoptosis Activator 2
Item : cc 650
Price : 50mg, $195; 100mg, $395; 200mg, $695, 1g, $1295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Apoptosis activator 2, a cell permeable indoledion compound, promotes the cytochrome c-dependent oligomerizatioin of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows weak or no effect on normal cells or cells that are deficient in caspase-3 or Apaf-1.[1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2003, 100, 7533.
[2] J. Neuroendocrinol. 2009, 21, 77-81.
 
 
Chemical Information
Molecular Weight (WM):
306.14
Formula:
C15H9Cl2NO2
CAS No:
79183-19-0
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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