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Product name : LY 364947
Item : cc 654
Price : 10mg, $95, 50mg, $295; 100mg, $495; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
LY364947 is a potent, selective ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM. Transforming growth factor-β signals through a cell surface heteromeric complex involving TGF-βRI And TGF-βRII. TGF-β Receptor I kinase is responsible for fibroblast proliferation and the accumulation of astrocytes around the fibrotic scar when injury occurs to cells. [1][2]
 
Reference:
[1] Mol. Cell Neurosci. 2010, 43, 177-187.
[2] Cancer Sci. 2009, 100, 173-180.
 
 
Chemical Information
Molecular Weight (WM):
272.30
Formula:
C17H12N4
CAS No:
396129-53-6
Purity:
≥ 98%
Synonyms:
LY-364947
 
DMSO ≥ 1 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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