Apoptosis
TGF-β Receptor
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Product name : LY 364947
Item : cc 654
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 396129-53-6
Molecular Weight : 272.3
Formula : C₁₇H₁₂N₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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LY364947 is a potent, selective ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM. Transforming growth factor-β signals through a cell surface heteromeric complex involving TGF-βRI And TGF-βRII. TGF-β Receptor I kinase is responsible for fibroblast proliferation and the accumulation of astrocytes around the fibrotic scar when injury occurs to cells. [1][2]
Reference:
[1] Mol. Cell Neurosci. 2010, 43, 177-187.
[2] Cancer Sci. 2009, 100, 173-180.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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