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Product name : A 83-01
Item : cc 656
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 909910-43-6
Molecular Weight : 421.52
Formula : C₂₅H₁₉N₅S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). B A-83-01 was found to be more potent in the inhibition of ALK5 than a previously described ALK-5 inhibitor, SB-431542, and also to prevent phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta.  [1][2]
 
Reference:
[1] Cancer Sci. 2005, 96, 791-800.
[2] Cancer Sci. 2010, 101, 2207-2213.
 
 
Chemical Information
Molecular Weight (WM):
421.52
Formula:
C25H19N5S
CAS No:
909910-43-6
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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