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Products > Neuro Signaling > 5-HT Receptro > SB 742457 (GSK 742457)
Product name : SB 742457 (GSK 742457)
Item : cc 657
Price : 10mg, $265; 50mg, $795; 100mg, $1395; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
SB-742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63. SB-742457 extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. SB742457 is generally safe and well tolerated and may be efficacious in Alzheimer disease. [1][2]
 
Reference:
[1] Curr. Alzheimer Res. 2010, 7, 374-385.
[2] Curr. Opin. Pharmacol. 2011, 11, 94-100.
 
 
Chemical Information
Molecular Weight (WM):
462.82
Formula:
C19H19N3O2S.3HCl
CAS No:
909910-43-6
Purity:
≥ 98%
Synonyms:
GSK-742457, GSK742457
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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