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Product name : AMG 900
Item : cc-2
Price : 200mg, $1750;500mg, $2350; 1g $2950; 2g, $4150
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 945595-80-2
Molecular Weight : 503.58
Formula : C₂₈H₂₁N₇OS
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
AMG 900 is a small-molecule inhibitor of Pan-aurora kinases with an IC50 of median 3.5 nM. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.[1][2]
 
Reference:
[1] Caner Res. 2010, 70, 9846-9854.
[2] Xenobiotica 2010, 41, 400-408.
 
 
Chemical Information
Molecular Weight (WM):
503.58
Formula:
C28H21N7OS
CAS No:
945595-80-2
Purity:
≥ 98%
Synonyms:
AMG900, AMG-900
 
DMSO ≥ 100 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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