Apoptosis
Sigma Receptor
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Product name : ARN 509
Item : cc 670
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 956104-40-8
Molecular Weight : 477.43
Formula : C₂₁H₁₅F₄N₅O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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ARN-509 is an androgen receptor (AR) antagonist with IC50 of 16 nM. ARN509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. [1]
Reference:
[1] Cancer Res. 2012, 72, 1494-1503.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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