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Product name : CYC 116
Item : cc-470
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 693228-63-6
Molecular Weight : 368.46
Formula : C₁₈H₂₀N₆OS
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
CYC 116 is an orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine protein kinases that are only expressed in actively dividing cells and are critical in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account for most of the mitogenic and chemotactic effects of vascular endothelial growth factor (VEGF) on adult endothelial cells.[1][2]
 
Reference:
[1] Curr. Pharm. Des. 2004, 10, 1011-1015.
[2] Xenobiotica 2010, 41, 400-408.
 
 
Chemical Information
Molecular Weight (WM):
368.46
Formula:
C18H20N6OS
CAS No:
693228-63-6, 1067881-58-6
Purity:
≥ 98%
Synonyms:
CYC116, CYC-116
 
DMSO ≥ 24 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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