Apoptosis
Telomerase
|
Product name : Tideglusib (NP 031112, NP12)
Item : cc 675
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 865854-05-3
Molecular Weight : 334.39
Formula : C₁₉H₁₄N₂O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 |
| Details: | ||||||||||||||||||||
Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM. Glycogen synthase kinase 3 (GSK-3), a proline/serine protein kinase ubiquitously expressed and involved in many cellular signaling pathways, plays a key role in the pathogenesis of Alzheimer's disease (AD) being probably the link between β-amyloid and tau pathology. Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy. [1][2]
Reference:
[1] J Biol. Chem. 2012, 287, 893-904.
[2] J Alzheimers Dis. 2013, 33, 205-215.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
| Related Products : |
|
|
|
|
||||||||
|
|
|
|
Chinese
Deutsch
Espanol
Francais
Italiano
Portugues
Japanese
Korean
Arabic
Russian