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Product name : PF 5274857
Item : cc 682
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1373615-35-0
Molecular Weight : 436.96
Formula : C₂₀H₂₅ClN₄O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively. Inhibition of the Smoothened (Smo) represents a promising therapeutic strategy for treating malignant tumors that are dependent on the Hedgehog (Hh) signaling pathway. PF5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.  [1]
 
Reference:
[1] Mol. Cancer Ther. 2012, 11, 57-65.
 
 
Chemical Information
Molecular Weight (WM):
436.96
Formula:
C20H25ClN4O3S
CAS No:
1373615-35-0
Purity:
≥ 98%
Synonyms:
PF 5274857
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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