Favorite  |  Set Home
Products > GPCR > Smoothened > PF 5274857
Product name : PF 5274857
Item : cc 682
Price : 10mg, $395; 50mg,$1175; 100mg, $1695; 200mg,$2475
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively. Inhibition of the Smoothened (Smo) represents a promising therapeutic strategy for treating malignant tumors that are dependent on the Hedgehog (Hh) signaling pathway. PF5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.  [1]
 
Reference:
[1] Mol. Cancer Ther. 2012, 11, 57-65.
 
 
Chemical Information
Molecular Weight (WM):
436.96
Formula:
C20H25ClN4O3S
CAS No:
1373615-35-0
Purity:
≥ 98%
Synonyms:
PF 5274857
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
LDE 225 (Erismodegib)
LDE 225 (Erismodegib)
Price: 10mg, $195; 50mg, $595; 100mg, $895; 200mg, $1455
Purmorphamine
Purmorphamine
Price: 10mg, $125; 50mg, $495; 100mg, $795; 200mg, $1395
BMS 833923
BMS 833923
Price: 200mg, $595; 500mg, $1295;
LY 2940680
LY 2940680
Price: 10mg, $295; 50mg, $850; 100mg, $1395; 200mg, $2395