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Products > Protease > Proteasome > Carfilzomib (PR 171)
Product name : Carfilzomib (PR 171)
Item : cc 684
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : We offer significant discount for bulky quantity order
Molecular Weight : 719.91
Formula : C₄₀H₅₇N₅O₇
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. [1][2]
 
Reference:
[1] Blood 2007, 110, 3281-3290.
[2] Curr. Cancer Drug Targets 2011, 11, 285-295.
 
 
Chemical Information
Molecular Weight (WM):
719.91
Formula:
C40H57N5O7
CAS No:
868540-17-4, 1140908-84-4 (TFA), 1140908-85-5 (methanesulfonate)
Purity:
≥ 98%
Synonyms:
PR171
 
DMSO ≥ 50 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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