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Product name : WP 1066
Item : cc 685
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 857064-38-1
Molecular Weight : 356.22
Formula : C₁₇H₁₄BrN₃O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells. WP-1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription-3, signal transducer and activator of transcription-5, and extracellular signal-regulated kinase-1/2 pathways in a dose- and time-dependent manner. WP1066 is active both in vitro and ex vivo and should be further developed for the treatment of neoplasms expressing the JAK2 V617F mutation. [1][2]
 
Reference:
[1] Cancer Res. 2007, 67, 11291-11299.
[2] Clin. Cancer Res. 2008, 14, 788-796.
 
 
Chemical Information
Molecular Weight (WM):
356.22
Formula:
C17H14BrN3O
CAS No:
857064-38-1
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 72 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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