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Products > Apoptosis > TNF-alpha > Bay 11-7082 (BAY 11-7821)
Product name : Bay 11-7082 (BAY 11-7821)
Item : cc 690
Price : 10mg, $95, 50mg, $375; 100mg, $595; 200mg, $895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Bay 11-7082 (BAY 11-7821) inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. The transcription factor NF-κB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. Bay 11-7082 leads to decreased NF-κB and subsequent decreased expression of adhesion molecules and also reversibly activates MAP kinases and stimulates apoptosis. [1][2]
 
Reference:
[1] Neurosci. Lett. 2005, 377, 147-151.
[2] Blood 2002, 100, 1828-1834.
 
 
Chemical Information
Molecular Weight (WM):
207.25
Formula:
C10H9NO2S
CAS No:
19542-67-7
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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