Apoptosis
KSp
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Product name : CCT 129202
Item : cc-472
Price : 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 942947-93-5
Molecular Weight : 497.02
Formula : C₂₃H₂₅ClN₈OS
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora B, and Aurora C, respectively.It showed high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines. CCT129202 causes the accumulation of human tumor cells with ≥4N DNA content, leading to apoptosis. The results showed that the CCT129202 is an ATP-competitive inhibitor of recombinant Aurora A kinase with a Ki of 49.8 nM. [1]
Reference:
[1] Mol. Cancer Ther. 2007, 6, 3147-3157.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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