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Products > JAK/STAT > Pim Kinase > SMI-4a
Product name : SMI-4a
Item : cc 717
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 327033-36-3
Molecular Weight : 273.23
Formula : C₁₁H₆F₃NO₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. The serine/threonine Pim kinases have been suggested to promote the activity of the rapamycin-sensitive mammalian target of rapamycin (mTORC1), which regulates cell growth and survival. Pim kinases are overexpressed in solid cancers and hematologic malignancies, and as such have become targets of small molecule inhibitors to prevent the progression of various cancers. [1][2]
 
Reference:
[1] J Med. Chem. 2009, 52, 74-86.
[2] Proc. Natl. Acad. Sci. USA 2011, 108, 528-533.
      
 
Chemical Information
Molecular Weight (WM):
273.23
Formula:
C11H6F3NO2S
CAS No:
327033-36-3   
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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