Favorite  |  Set Home
Products > Aurora/Ksp > KSp > AZD 4877
Product name : AZD 4877
Item : cc 722
Price : 10mg, $295; 50mg, $795; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
             [Next Product]→


Details:
AZD-4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Eg5 is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. [1][2]
                                                                                       
Reference:
[1] Invest. New Drugs 2012, 30, 1107-1115.
[2] Cancer Chemother. Pharmacol. 2012, 69, 165-172.
      
 
Chemical Information
Molecular Weight (WM):
503.66
Formula:
C28H33N5O2S
CAS No:
1176760-49-8 
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
ARRY 520
ARRY 520
Price: 10mg, $295; 50mg, $795; 100mg, $1395; 200mg, $2395
MPS-1-IN-1
MPS-1-IN-1
Price: 10mg, $295; 50mg, $795; 100mg, $1295; 200mg, $1995
SB 743921
SB 743921
Price: 10mg, $275; 50mg, $795; 100mg, $1295; 200mg, $2295
Ispinesib (SB 715992, CK 0238273)
Ispinesib (SB 715992, CK 0238273)
Price: 10mg, $275; 50mg, $725; 100mg, $1295; 200mg, $2295
AZ 3146
AZ 3146
Price: 10mg, $175; 50mg, $395; 100mg, $645; 200mg, $995