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Product name : SNS 314
Item : cc-347
Price : 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1146618-41-8
Molecular Weight : 527.04
Formula : C₁₉H₁₉ClN₆O₄S₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
SNS 314 is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50 = 9.0 nM), Aurora kinase B (IC50 = 31 nM) and Aurora kinase C (IC50 = 3.4 nM). Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.[1][2]
 
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 4880-4884.
[2] Mol. Cancer Ther. 2009, 8, 930-939.
 
 
Chemical Information
Molecular Weight (WM):
527.04
Formula:
C18H15ClN6OS2·CH4O3S
CAS No:
1146618-41-8
Purity:
≥ 98%
Synonyms:
SNS-314, SNS314
 
DMSO ≥ 105 mg/mL
Solubility: (R.T.: 25℃):
Water ≥ 6 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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