Product name : SNS 314
Item : cc-347
Price : 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1146618-41-8
Molecular Weight : 527.04
Formula : C₁₉H₁₉ClN₆O₄S₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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SNS 314 is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50 = 9.0 nM), Aurora kinase B (IC50 = 31 nM) and Aurora kinase C (IC50 = 3.4 nM). Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.[1][2]
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 4880-4884.
[2] Mol. Cancer Ther. 2009, 8, 930-939.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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