Favorite  |  Set Home
Products > Aurora/Ksp > Aurora > SNS 314
Product name : SNS 314
Item : cc-347
Price : 10mg, $175; 50mg, $595; 100mg, $945; 200mg, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
SNS 314 is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50 = 9.0 nM), Aurora kinase B (IC50 = 31 nM) and Aurora kinase C (IC50 = 3.4 nM). Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.[1][2]
 
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 4880-4884.
[2] Mol. Cancer Ther. 2009, 8, 930-939.
 
 
Chemical Information
Molecular Weight (WM):
527.04
Formula:
C18H15ClN6OS2·CH4O3S
CAS No:
1146618-41-8
Purity:
≥ 98%
Synonyms:
SNS-314, SNS314
 
DMSO ≥ 105 mg/mL
Solubility: (R.T.: 25℃):
Water ≥ 6 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

Related Products :
Hesperadin
Hesperadin
Price: 10mg, $275; 50mg, $895; 100mg, $1295; 200mg, $2095
MK 5108 (VX 689)
MK 5108 (VX 689)
Price: 10mg, $275; 50mg, $695; 100mg, $1295; 200mg, $2295
GSK 1070916
GSK 1070916
Price: 10mg, $295; 50mg, $795; 100mg, $1395; 200mg, $2395
AMG 900
AMG 900
Price: 10mg, $275; 50mg, $795; 100mg, $1295; 200mg, $2295
CYC 116
CYC 116
Price: 10mg, $95, 50mg, $295; 100mg, $495; 200mg, $955
MLN 8054
MLN 8054
Price: 10mg, $275; 50mg, $845; 100mg, $1295; 200mg, $2295
ENMD 2076
ENMD 2076
Price: 200mg, $945; 500mg, $1785
PHA 680632
PHA 680632
Price: 10mg, $275; 50mg, $895; 100mg, $1295; 200mg, $2095