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Products > Apoptosis > Bcl-2 > ABT 199 (GDC 0199)
Product name : ABT 199 (GDC 0199)
Item : cc776
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 1257044-40-8
Molecular Weight : 868.44
Formula : C₄₅H₅₀ClN₇O₇S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
ABT-199 (GDC0199, RG7601) is a Bcl-2-selective inhibitor with Ki < 0.010 nM. GDC-0199 (RG-7601) is a novel small molecule Bcl-2 selective inhibitor designed to restore apoptosis, also known as programmed cell death, by blocking the function of a pro-survival Bcl-2 family protein. The Bcl-2 family proteins, which are expressed at high levels in many tumors, play a central role in regulating apoptosis and, consequently, are thought to impact tumor formation, tumor growth and resistance.  [1][2]
 
Reference:
[1] Nat. Med. 2013, 19, 202-208.
[2] Cancer Cell. 2013, 23, 139-141.
 
Chemical Information
Molecular Weight (WM):
868.44
Formula:
C45H50ClN7O7S
CAS No:
1257044-40-8.
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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