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Product name : Eltrombopag (SB-497115-GR, Promacta, Revolade)
Item : cc732
Price : 1g, $650;2g, $1050;
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 496775-61-2
Molecular Weight : 442.47
Formula : C₂₅H₂₂N₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition of hERG K+ channel tail current. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. [1][2]
 
Reference:
[1] Clin. Ther. 2011, 33, 1560-1576.
[2] J Neurooncol. 2012, 106, 427-429.
                                          
Chemical Information
Molecular Weight (WM):
442.47
Formula:
C25H22N4O4
CAS No:
496775-61-2
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 89 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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