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Product name : Hesperadin
Item : cc-473
Price : 10mg, $275; 50mg, $895; 100mg, $1295; 200mg, $2095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Hesperadin is an ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM. Hesperadin prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol- and taxol-treated HeLa cells. [1][2]
 
Reference:
[1] Molecular Cell, 2005, 18, 379-391.
[2] Mol. Microbiol. 2009, 72, 442-458.
 
 
Chemical Information
Molecular Weight (WM):
516.65
Formula:
C29H32lN4O3S
CAS No:
422513-13-1
Purity:
≥ 98%
Synonyms:
N/A
 
DMSO ≥ 103 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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