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Product name : GSK 1070916
Item : cc-423
Price : 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 942918-07-2
Molecular Weight : 507.63
Formula : C₃₀H₃₃N₇O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
GSK1070916 is a novel ATP competitive inhibitor that is highly potent and selective for Aurora B/C kinases. Human tumor cells treated with GSK1070916 show dose-dependent inhibition of phosphorylation on serine 10 of Histone H3, a substrate specific for Aurora B kinase. Moreover, GSK1070916 inhibits the proliferation of tumor cells with EC50 values of <10 nmol/L in over 100 cell lines spanning a broad range of tumor types. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2009, 8, 1808-1817.
[2] J Med. Chem. 2010, 53, 3973-4001.
 
 
Chemical Information
Molecular Weight (WM):
507.63
Formula:
C30H33lN7O
CAS No:
942918-07-2
Purity:
≥ 98%
Synonyms:
GSK1070916, GSK-1070916
 
DMSO ≥ 102 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 46 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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