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Product name : Dabrafenib (GSK 2118436)
Item : cc755
Price : 50mg, $195; 100mg, $395; 200mg, $695, 1g, $1295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Dabrafenib (GSK-2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2012, 11, 909-920.
[2] JAMA Dermatol. 2013, 149, 322-326. .
 
Chemical Information
Molecular Weight (WM):
519.56
Formula:
C23H20F3N5O2S2
CAS No:
1195765-45-7, 1195768-06-9 (methanesulfonic acid)
Purity:
≥ 98%
Synonyms:
GSK2118436
 
DMSO ≥ 30 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years    -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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