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Product name : JAK Inhibitor I (Merck 5)
Item : cc762
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 457081-03-7
Molecular Weight : 309.34
Formula : C₁₈H₁₆FN₃O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
JAK Inhibitor I displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). JAK1 (Janus kinase 1), JAK2 and JAK3 belong to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated JAK1, JAK2 and JAK3. [1][2]
 
Reference:
[1] Cancer Res. 2006, 66, 9714-9721.
[2] Biol. Pharm. Bull. 2009, 32, 45-50.
 
Chemical Information
Molecular Weight (WM):
309.34
Formula:
C18H16FN3O
CAS No:
457081-03-7
Purity:
≥ 98%
Synonyms:
Merck 5
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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