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Product name : PIK 75
Item : cc766
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 372196-77-5
Molecular Weight : 488.74
Formula : C₁₆H₁₅BrClN₅O₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Details:
PIK-75 blocks production of PIP2 and/or PIP3, phosphorylation of Akt, and activation of mTORC1 in adipocytes and myotubes. PI 3-kinase (PI3K) catalyzes the synthesis of the second messengers PtdIns-(3)-P, PtdIns-(3,4)-P2, and PtdIns-(3,4,5)-P3. PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM. PIK-75 inhibits p110γ and p110β considerably less effectively.  [1][2]
 
Reference:
[1] Biochem. Biophys. Res. Commun. 2009, 381, 577-581.
[2] Blood 2007, 110, 4243-4252.
 
Chemical Information
Molecular Weight (WM):
452.28
Formula:
C16H14BrN5O4S
CAS No:
372196-67-3
Purity:
≥ 98%
Synonyms:
 PIK75
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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