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Product name : MLN 8054
Item : cc-475
Price : 10mg, $275; 50mg, $845; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
MLN 8054 is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. MLN 8054 inhibits recombinant Aurora A kinase activity in vitro and is selective for Auroao A (IC50 = 4 nM) over the family member Aurora B (IC50 = 0.17 μM). MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.[1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. 2007, 104, 4106-4111.
[2] Mol. Cell Biol. 2007, 27, 4513-4525.
 
 
Chemical Information
Molecular Weight (WM):
476.86
Formula:
C25H15ClF2N4O2
CAS No:
869363-13-3, 869366-15-4 (sodium salt)
Purity:
≥ 98%
Synonyms:
MLN-8054, MLN8054
 
DMSO ≥ 95 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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