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Product name : PHA 680632
Item : cc-476
Price : 200mg, $1750;500mg, $2350; 1g $2950; 2g, $4150
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 398493-79-3
Molecular Weight : 501.62
Formula : C₂₈H₃₅N₇O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27, 135 and 120 nM, respectively). This agent has a high potential for further development as an anticancer therapeutic. PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses. The IC50 of PHA-680632 for cell anti-proliferation ranged from 0.11 µM to 5.6 µM. [1]
 
 
Reference:
[1] Clin. Cancer Res. 2006, 12, 4080-4089.
 
 
Chemical Information
Molecular Weight (WM):
501.62
Formula:
C28H35N7O2
CAS No:
398493-79-3
Purity:
≥ 98%
Synonyms:
PHA-680632
 
DMSO ≥ 100 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 100 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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