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Product name : RN 486
Item : cc788
Price : 10mg, $495; 50mg, $1290;100mg, $2295; 200mg, $3795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays in multiple cell types, blocking Fcε receptor cross-linking-induced degranulation in mast cells (IC(50) = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC(50) = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC(50) = 21.0 nM).  [1][2]
 
Reference:
[1] Immunol. Lett. 2013, 150, 97-104.
[2] J Pharmacol. Exp. Ther. 2012, 341, 90-103.
 
Chemical Information
Molecular Weight (WM):
606.69
Formula:
C35H35FN6O3
CAS No:
1242156-23-5
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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