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Products > Receptor Tyrosine Kinase > ALK > Brigatinib (Synonyms: AP-26113)
Product name : Brigatinib (Synonyms: AP-26113)
Item : cc792
Price : 1g, $650;2g, $1050;
contact : Send inquiry to: info@acesobio.com
CAS : 1197953-54-0
Molecular Weight : 584.09
Formula : C₂₉H₃₉ClN₇O₂P
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
AP-26113 is a potent ALK inhibitor for ALK, FER, ROS/ROS1, FLT3 and FES/FPS with IC50 of 0.62 nM, 1.3 nM, 1.9 nM, 2.1 nM and 3.4 nM, respectively. Dual ALK/EGFR inhibitor AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types. [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2011, 108, 7535-7340.
[2] Mol. Cancer Res. 2013, 11, 122-132.
 
Chemical Information
Molecular Weight (WM):
529.01
Formula:
C26H34ClN6O2P
CAS No:
1197958-12-5
Purity:
≥ 98%
Synonyms:
AP26113
 
DMSO ≥ 45 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 106 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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