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Product name : VX 680
Item : cc-202
Price : 25mg, $39; 50mg, $75; 100mg, $125; 250mg, $1950
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Tozasertib(VX 680, MK 0457)is a synthetic, small-molecule Aurora kinase A,Aurora kinase B, and Aurora kinase C inhibitor with IC50 value of 0.6, 18,4.6 nM respectively. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis. [1][2]
 
Reference:
[1] Nat. Med. 2004, 10, 262-7.
[2] Cancer 2005, 5, 42-50.
 
 
Chemical Information
Molecular Weight (WM):
464.59
Formula:
C23H28N8OS
CAS No:
639089-54-6
Purity:
≥ 98%
Synonyms:
VX680, MK-0457, VX-680, MK0457
 
DMSO ≥ 93 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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