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Product name : Odanacatib (MK 0822)
Item : cc803
Price : 10mg, $395; 50mg,$1095; 100mg, $1895; 200mg,$2475
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Odanacatib (MK-0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. [1][2]
 
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 923-928.
[2] J Bone Miner. Res. 2011, 26, 252-262.
 
Chemical Information
Molecular Weight (WM):
525.56
Formula:
C25H27F4N3O3S
CAS No:
603139-19-1
Purity:
≥ 98%
Synonyms:
MK0822
 
DMSO ≥ 105 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years    -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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