Favorite  |  Set Home
Products > Others > > Odanacatib (MK 0822)
Product name : Odanacatib (MK 0822)
Item : cc803
Price : 200mg, $1250;500mg, $2090; 1g, $2995;
contact : Send inquiry to: info@acesobio.com
CAS : 603139-19-1
Molecular Weight : 525.56
Formula : C₂₅H₂₇F₄N₃O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Odanacatib (MK-0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. [1][2]
 
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 923-928.
[2] J Bone Miner. Res. 2011, 26, 252-262.
 
Chemical Information
Molecular Weight (WM):
525.56
Formula:
C25H27F4N3O3S
CAS No:
603139-19-1
Purity:
≥ 98%
Synonyms:
MK0822
 
DMSO ≥ 105 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years    -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
GJ-103
GJ-103
Price: 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
Tirofiban (Aggrastat)
Tirofiban (Aggrastat)
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
Darbufelone
Darbufelone
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
Eliglustat (Synonyms: Genz 99067)
Eliglustat (Synonyms: Genz 99067)
Price: 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795
Atglistatin
Atglistatin
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
TPT-260
TPT-260
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
MS436
MS436
Price: 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
SC 26196
SC 26196
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590