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Products > Receptor Tyrosine Kinase > Bcr-Abl > WP 1130 (degrasyn)
Product name : WP 1130 (degrasyn)
Item : cc804
Price : 10mg, $245; 50mg, $795; 100mg, $1295; 200mg, $1895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
WP-1130 (degrasyn) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM. WP1130was more effective in reducing leukemic versus normal hematopoietic colony formation and strongly inhibited colony formation of cells derived from patients with T315I mutant Bcr/Abl-expressing CML in blast crisis. [1][2]
 
Reference:
[1] Blood 2007, 109, 3470-3478.
[2] Cancer Res. 2007, 67, 3912-3918.
 
Chemical Information
Molecular Weight (WM):
384.27
Formula:
C19H18BrN3O
CAS No:
856243-80-6
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 77 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 50 mg/mL
 
2 years    -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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