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Products > DNA damage > Topoisomerase > Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin)
Product name : Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin)
Item : cc808
Price : 10mg, $125; 50mg, $295; 100mg, $495; 200mg, $825
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds. [1][2]
 
Reference:
[1] J Chemother. 2005, 17, 663-667.
[2] Hematology. 2004, 9, 217-221.
 
Chemical Information
Molecular Weight (WM):
497.49
Formula:
C26H27NO9
CAS No:
58957-92-9, 57852-57-0 (HCl)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 107 mg/mL
Solubility (25℃)
Water ≥ 10 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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