Apoptosis
Sigma Receptor
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Product name : Org 27569 (ab120342)
Item : cc-477
Price : 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 868273-06-7
Molecular Weight : 409.95
Formula : C₂₄H₂₈ClN₃O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor (pEC50 = 8.24). Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulating second messenger signaling once bound, and so in practice behaves as an insurmountable antagonist of CB1 receptor function.[1][2]
Reference:
[1] Mol. Pharmacol. 2005, 68, 1484-1495.
[2] Trends Phramacol. Sci. 2007, 28, 567-572.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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