Product name : PF-543
Item : CR1946
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 1415562-82-1
Molecular Weight : 465.6
Formula : C₂₇H₃₁NO₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Chemical Information
Biological Activity of PF-543
PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
References on PF-543[1]. Schnute ME, McReynolds MD, Kasten T et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88. |
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