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Product name : PF-543
Item : CR1946
Price : 100mg, $945; 200mg, $1485
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CAS : 1415562-82-1
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Details:
 

Chemical Information

M.Wt 465.6 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C27H31NO4S
CAS No 1415562-82-1
Solubility

DMSO



Biological Activity of PF-543

 

PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
IC50 value: 3.6 nM (Ki)
Target: SphK1
PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.

 

[1]. Schnute ME, McReynolds MD, Kasten T et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.

[2]. Lynch KR. Building a better sphingosine kinase-1 inhibitor. Biochem J. 2012 May 15;444(1):e1-2.


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