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Product name : DMH1
Item : CR1945
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995 ;
contact : Send inquiry to: info@acesobio.com
CAS : 1206711-16-1
Molecular Weight : 380.44
Formula : C₂₄H₂₀N₄O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
 

Chemical Information

M.Wt 380.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H20N4O
CAS No 1206711-16-1
Solubility

DMSO



Biological Activity of DMH-1

 

DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2.
IC50 value: 27/107.9/<5 nM(ALK1/2/3) [1]
Target: ALK inhibitor
DMH-1 shows the most selectivity within these three compounds(LDN-193189, DMH-1 and dorsomorphin) [1]. DMH1 is a highly selective small molecule BMP-inhibitor for its potential to replace Noggin in the neuralization of hiPSCs. DMH1-induced neural progenitors can be differentiated into β3-tubulin expressing neurons, a subset of which also express tyrosine hydroxylase [2].

 

[1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
[2]. Neely MD, et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci. 2012 Jun 20;3(6):482-91.


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