Product name : DMH1
Item : CR1945
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995 ;
contact : Send inquiry to: info@acesobio.com
CAS : 1206711-16-1
Molecular Weight : 380.44
Formula : C₂₄H₂₀N₄O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Chemical Information
Biological Activity of DMH-1
DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2.
References on DMH-1[1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. |
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